https://www.ceesdekker.net - An Overview
https://www.ceesdekker.net - An Overview
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It had been only inside the nineteen nineties however, when nanotechnology had State-of-the-art to some amount the place one molecules may be manipulated, that the very first experimental products began to seem.
[Laughs] ‘It was certainly an excellent danger! At the time, I was well aware that it could go wrong Which I could develop into a lot less profitable, but I just dismissed that. Curiosity has usually been my strongest driving force. And luckily everything worked out.’
Due to the fact 2000, Dekker has shifted the primary concentration of his function to biophysics exactly where he scientific tests the properties of one biomolecules and cells utilizing the resources of nanotechnology. This variation of industry was pushed by his fascination for your impressive performing of Organic molecular structures, along with with the extensive-term perspective that a lot of appealing discoveries is usually expected Within this area.[five] Present-day strains of research in his biophysics group are within the areas of:[6]
We create point-of-treatment diagnostics take a look at of neglected tropical ailments inside useful resource-minimal options, according to Crspr/Cas9 detecting of pathogen’s DNA in body fluids.
SMC complexes can go Bodily roadblocks bigger ceesdekker.net than their ring dimension, indicating a nontopological mechanism for DNA loop extrusion
We use nanofabricated microfluidic buildings to sample spatial boundaries for micro organism and biomimetic vesicles with reconstituted protein networks which evaluate the basic part of spatial confinement on the molecular and cellular amount. Our jobs consist of the following:
2000, discovery that nanotubes can carry incredible large present densities; solved the controversial difficulty of electronic transport as a result of DNA molecules by measurements of insulating behavior at The only molecule stage; and demonstration of the AFM method for solitary-molecule manipulation of nanotubes
Understanding fundamental procedures regulating the spatial and dynamic organisation of your DNA in live cells.
Dekker commenced his analysis on one carbon nanotubes in 1993 when he build a fresh line of research to check electrical transport as a result of solitary organic molecules involving nanoelectrodes. In 1996 a breakthrough was realized with carbon nanotubes. This was obtained in the collaboration Using the team of Nobel laureate Richard Smalley. STM and nanolithography strategies were being accustomed to reveal that these nanotubes are quantum wires at The only-molecule amount, with exceptional Actual physical Homes.
Testing pseudotopological and nontopological styles for SMC-pushed DNA loop extrusion towards roadblock-traversal experiments
Character Physics thanks the nameless reviewers for their contribution into the peer overview of this get the job done.
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Case in point (2) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim from the pore is highlighted in purple, along with a 3D rendering with the motion on the DNA rod is displayed.